A coumarin-modified tris[4-(4-pyridyl)phenyl]amine compound was encapsulated in the cavity of cucurbit[8]uril with a 2 : 3 stoichiometric ratio, which not only effectively enhances the guest fluorescence emission with a hypsochromic shift of about 51 nm by macrocycle confinement, but also allows cascade assembly with β-cyclodextrin-grafted hyaluronic acid (HACD) to construct a ternary supramolecular network. Furthermore, doping of sulfo-cyanine 5 into the β-cyclodextrin cavity of HACD through host–guest interaction achieved a high efficiency Förster resonance energy transfer system from the supramolecular network to dyes, which was successfully applied to near-infrared mitochondria-targeted imaging in HeLa cells.

中文翻译：

---

葫芦[8]脲介导的三苯胺香豆素衍生物级联组装用于近红外靶向细胞成像


将香豆素修饰的三[4-(4-吡啶基)苯基]胺化合物以2 : 3的化学计量比封装在葫芦[8]脲的空腔中，不仅有效增强了客体荧光发射，而且低变色位移为通过大环限制约51 nm，但也允许与β-环糊精接枝透明质酸（HACD）级联组装以构建三元超分子网络。此外，通过主客体相互作用将磺基花青5掺杂到HACD的β-环糊精空腔中，实现了从超分子网络到染料的高效Förster共振能量转移系统，该系统成功应用于近红外线粒体靶向成像海拉细胞。