Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2024-07-15 , DOI: 10.1038/s41577-024-01057-x Michael H Lee 1 , Sean-Paul Nuccio 1 , Ipsita Mohanty 2 , Lee R Hagey 3 , Pieter C Dorrestein 2, 4, 5 , Hiutung Chu 5, 6, 7 , Manuela Raffatellu 1, 5, 7
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Bile acids are increasingly appearing in the spotlight owing to their novel impacts on various host processes. Similarly, there is growing attention on members of the microbiota that are responsible for bile acid modifications. With recent advances in technology enabling the discovery and continued identification of microbially conjugated bile acids, the chemical complexity of the bile acid landscape in the body is increasing at a rapid pace. In this Review, we summarize our current understanding of how bile acids and the gut microbiota interact to modulate immune responses during homeostasis and disease, with a particular focus on the gut.
中文翻译：
胆汁酸和微生物群如何相互作用以塑造宿主免疫力
由于胆汁酸对各种宿主过程的新影响，它们越来越多地成为人们关注的焦点。同样，人们越来越关注负责胆汁酸修饰的微生物群成员。随着技术的最新进步，人们能够发现和持续鉴定微生物结合的胆汁酸，体内胆汁酸景观的化学复杂性正在迅速增加。在这篇综述中，我们总结了我们目前对胆汁酸和肠道微生物群如何在体内平衡和疾病期间相互作用以调节免疫反应的理解，特别关注肠道。
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