Genetics research has potential to alleviate the burden of mental disorders in low- and middle-income-countries through identification of new mechanistic pathways which can lead to efficacious drugs or new drug targets. However, there is currently limited genetics data from Africa. The Uganda Genome Resource provides opportunity for psychiatric genetics research among underrepresented people from Africa. We aimed at determining the prevalence and correlates of major depressive disorder (MDD), suicidality, post-traumatic stress disorder (PTSD), alcohol abuse, generalised anxiety disorder (GAD) and probable attention-deficit hyperactivity disorder (ADHD) among participants of the Uganda Genome Resource. Standardised tools assessed for each mental disorder. Prevalence of each disorder was calculated with 95% confidence intervals. Multivariate logistic regression models evaluated the association between each mental disorder and associated demographic and clinical factors. Among 985 participants, prevalence of the disorders were: current MDD 19.3%, life-time MDD 23.3%, suicidality 10.6%, PTSD 3.1%, alcohol abuse 5.7%, GAD 12.9% and probable ADHD 9.2%. This is the first study to determine the prevalence of probable ADHD among adult Ugandans from a general population. We found significant association between sex and alcohol abuse (adjusted odds ratio [AOR] = 0.26 [0.14,0.45], p < 0.001) and GAD (AOR = 1.78 [1.09,2.49], p = 0.019) respectively. We also found significant association between body mass index and suicidality (AOR = 0.85 [0.73,0.99], p = 0.041), alcohol abuse (AOR = 0.86 [0.78,0.94], p = 0.003) and GAD (AOR = 0.93 [0.87,0.98], p = 0.008) respectively. We also found a significant association between high blood pressure and life-time MDD (AOR = 2.87 [1.08,7.66], p = 0.035) and probable ADHD (AOR = 1.99 [1.00,3.97], p = 0.050) respectively. We also found a statistically significant association between tobacco smoking and alcohol abuse (AOR = 3.2 [1.56,6.67], p = 0.002). We also found ever been married to be a risk factor for probable ADHD (AOR = 2.12 [0.88,5.14], p = 0.049). The Uganda Genome Resource presents opportunity for psychiatric genetics research among underrepresented people from Africa.

遗传学研究有潜力通过识别新的机制途径来减轻低收入和中等收入国家精神障碍的负担，从而产生有效的药物或新的药物靶点。然而，目前来自非洲的遗传学数据有限。乌干达基因组资源为非洲代表性不足的人群进行精神病遗传学研究提供了机会。我们的目的是确定参与者中重度抑郁症（MDD）、自杀、创伤后应激障碍（PTSD）、酗酒、广泛性焦虑症（GAD）和可能的注意力缺陷多动障碍（ADHD）的患病率和相关性。乌干达基因组资源。针对每种精神障碍进行评估的标准化工具。每种疾病的患病率均按 95% 置信区间计算。多变量逻辑回归模型评估了每种精神障碍与相关人口统计和临床因素之间的关联。在 985 名参与者中，这些疾病的患病率是：当前 MDD 19.3%、终生 MDD 23.3%、自杀倾向 10.6%、PTSD 3.1%、酗酒 5.7%、GAD 12.9% 和可能 ADHD 9.2%。这是第一项确定乌干达普通人群中可能患有多动症的患病率的研究。我们发现性与酗酒之间存在显着关联（调整后优势比 [AOR] = 0.26 [0.14,0.45]，p < 0.001）和 GAD（AOR = 1.78 [1.09,2.49]，p = 0.019）。我们还发现体重指数与自杀率（AOR = 0.85 [0.73,0.99]，p = 0.041）、酗酒（AOR = 0.86 [0.78,0.94]，p = 0.003）和GAD（AOR = 0.93 [0.87）之间存在显着关联。 ，0.98]，p = 0.008）。我们还发现高血压与终生 MDD 之间存在显着关联（AOR = 2.87 [1.08,7.66]，p = 0。035）和可能的 ADHD（AOR = 1.99 [1.00,3.97]，p = 0.050）。我们还发现吸烟和酗酒之间存在统计学上显着的关联（AOR = 3.2 [1.56,6.67]，p = 0.002）。我们还发现，曾经结婚是可能患 ADHD 的一个危险因素（AOR = 2.12 [0.88,5.14]，p = 0.049）。乌干达基因组资源为非洲代表性不足的人群提供了精神遗传学研究的机会。