Low‐dose immune tolerance protocols use doses of factor VIII of less than 50 IU/kg/day to induce immune tolerance. Such protocols are chosen for a variety of reasons including cost, patient acceptability and ease of administration. Early published reports of low‐dose protocols appeared in 1981, described small numbers of patients and moderate success. It was proposed that such protocols might modify inhibitor responses from high to low. Later reports are sparse and clinical success is again moderate. Useful treatment and expectation guidelines have emerged from experience with these protocols, and improvements for patients with inhibitors can be achieved. Consideration of immunological success, however, raises doubts about whether real immune tolerance is achieved with such protocols.

中文翻译：

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使用低剂量因子 VIII 的免疫耐受方案：文献综述


低剂量免疫耐受方案使用低于 50 IU/kg/天的因子 VIII 剂量来诱导免疫耐受。选择此类方案的原因有多种，包括成本、患者可接受性和易于给药。早期发表的低剂量方案报告出现于 1981 年，描述了少量患者和中等成功。有人提出，此类方案可能会将抑制剂反应从高改为低。后来的报道很少，临床成功率也很低。从这些方案的经验中得出了有用的治疗和期望指南，并且可以实现对抑制剂患者的改善。然而，考虑到免疫学的成功，人们对此类方案是否能实现真正的免疫耐受产生了怀疑。