Objectives To investigate the physical activity (PA) intensity associated with cardiometabolic health when considering the mediating role of cardiorespiratory fitness (CRF). Methods A subsample of males and females aged 50–64 years from the cross-sectional Swedish CArdioPulmonary bioImage Study was investigated. PA was measured by accelerometry and CRF by a submaximal cycle test. Cardiometabolic risk factors, including waist circumference, systolic blood pressure, high-density lipoprotein, triglycerides and glycated haemoglobin, were combined to a composite score. A mediation model by partial least squares structural equation modelling was used to analyse the role of CRF in the association between PA and the composite score. Results The cohort included 4185 persons (51.9% female) with a mean age of 57.2 years. CRF mediated 82% of the association between PA and the composite score. The analysis of PA patterns revealed that moderate intensity PA explained most of the variation in the composite score, while vigorous intensity PA explained most of the variation in CRF. When including both PA and CRF as predictors of the composite score, the importance of vigorous intensity increased. Conclusion The highly interconnected role of CRF in the association between PA and cardiometabolic health suggests limited direct effects of PA on cardiometabolic health beyond its impact on CRF. The findings highlight the importance of sufficient PA intensity for the association with CRF, which in turn is linked to better cardiometabolic health. Data may be obtained from a third party and are not publicly available. The data cannot be freely available since it contains sensitive personal information. Information regarding application for accessing the data can be found on the SCAPIS study organisation website [www.scapis.org][1]. [1]: http://www.scapis.org

中文翻译：

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与健身相关的身体活动强度解释了加速度计数据与 50-64 岁人群心脏代谢健康之间的大部分关联


目的 在考虑心肺健康 （CRF） 的中介作用时，探讨与心脏代谢健康相关的体力活动 （PA） 强度。方法 调查了来自横断面瑞典 CArdioPulmonary 生物图像研究的 50-64 岁男性和女性的子样本。通过加速度测定法测量 PA，通过次最大循环测试测量 CRF。将心脏代谢危险因素，包括腰围、收缩压、高密度脂蛋白、甘油三酯和糖化血红蛋白，合并到综合评分中。使用偏最小二乘结构方程模型的中介模型来分析 CRF 在 PA 与综合评分之间关联中的作用。结果 该队列包括 4185 人 （51.9% 为女性），平均年龄为 57.2 岁。CRF 介导了 PA 与综合评分之间 82% 的关联。PA 模式分析显示，中等强度 PA 解释了综合评分的大部分变化，而高强度 PA 解释了 CRF 的大部分变化。当将 PA 和 CRF 作为综合评分的预测因子时，剧烈强度的重要性增加。结论 CRF 在 PA 与心脏代谢健康之间的关联中高度相互关联的作用表明，除了对 CRF 的影响外，PA 对心脏代谢健康的直接影响有限。研究结果强调了足够的 PA 强度对 CRF 相关的重要性，这反过来又与更好的心脏代谢健康有关。数据可能从第三方获得，并且不会公开。这些数据不能免费获得，因为它包含敏感的个人信息。 有关申请访问数据的信息，请访问 SCAPIS 研究组织网站 [www.scapis.org][1]。[1]：http://www.scapis。组织