otype is largely characterized by the complications of chronic metabolic acidosis (MA): stunted growth, bone abnormalities, and nephrocalcinosis and nephrolithiasis that develop as the consequence of hypercalciuria and hypocitraturia. All these manifestations are preventable with early and sustained correction of MA with alkali therapy. The optimal target for plasma bicarbonate should be as close as possible to the range considered normal by current standards (between 23 and 28 mEq/L.). Most of the benefits of alkali therapy are tangible early in the course of the disease in childhood, but life-long treatment is required to prevent the vast array of complications attributable to chronic MA....

中文翻译：

---

原发性远端肾小管性酸中毒：代谢性酸中毒的最佳纠正


o型的主要特征是慢性代谢性酸中毒（MA）的并发症：生长发育迟缓、骨骼异常以及因高钙尿症和低柠檬酸尿症而发生的肾钙质沉着症和肾结石。所有这些表现都是可以通过碱疗法早期和持续纠正 MA 来预防的。血浆碳酸氢盐的最佳目标应尽可能接近当前标准认为的正常范围（23 至 28 mEq/L 之间）。碱疗法的大部分益处在儿童病程早期就显而易见，但需要终生治疗以预防慢性 MA 引起的大量并发症......