We describe the applicability of a nickelocene/phosphine system as a versatile precursor of catalytically active complexes in Suzuki-Miyaura cross-coupling. The most popular commercially available phosphines were tested. Two sets of reaction conditions were developed depending on the nature of boronic acid. The described methods work for both bromide and chloride electrophiles. Nickelocene/phosphine precatalyst was successfully applied in the synthesis of various biaryl derivatives, including structures with two heteroaromatic rings coupled together.

中文翻译：

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使用方便易得的镍茂/磷化氢预催化剂进行铃木-宫浦交叉偶联


我们描述了二茂镍/膦系统作为铃木-宫浦交叉偶联中催化活性配合物的多功能前体的适用性。对最流行的市售膦进行了测试。根据硼酸的性质开发了两组反应条件。所述方法适用于溴化物和氯化物亲电子试剂。茂镍/膦预催化剂已成功应用于各种联芳基衍生物的合成，包括两个杂芳环偶联在一起的结构。