Association between synovial tissue damage and pain in late-stage knee osteoarthritis: A cross-sectional study,Osteoarthritis and Cartilage

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Association between synovial tissue damage and pain in late-stage knee osteoarthritis: A cross-sectional study
Osteoarthritis and Cartilage ( IF 7.2 ) Pub Date : 2024-07-04 , DOI: 10.1016/j.joca.2024.06.015
Holly T Philpott ₁ , Trevor B Birmingham ₁ , McKenzie M Carter ₂ , Matthew J Cecchini ₃ , J Robert Giffin ₄ , Edward M Vasarhelyi ₅ , Steven J MacDonald ₄ , Brent A Lanting ₅ , C Thomas Appleton ₆ ,

Affiliation

Faculty of Health Sciences, University of Western Ontario, London, ON N6G 1H1, Canada,; Bone and Joint Institute, University of Western Ontario, London Health Sciences Centre-University Hospital, London, ON N6A 5B5, Canada.
Bone and Joint Institute, University of Western Ontario, London Health Sciences Centre-University Hospital, London, ON N6A 5B5, Canada; Physiology & Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Pathology & Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Bone and Joint Institute, University of Western Ontario, London Health Sciences Centre-University Hospital, London, ON N6A 5B5, Canada; Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Bone and Joint Institute, University of Western Ontario, London Health Sciences Centre-University Hospital, London, ON N6A 5B5, Canada; Physiology & Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

To identify the presence and distribution of histopathological features of synovial inflammation and tissue damage, and to test their associations with ultrasound (US) imaging measures of synovitis and patient-reported measures of pain in knee osteoarthritis (OA).

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