Improving the precision of gene correction through RNA base editing typically involves a trade-off with efficiency. We find using G•U wobble base pairs is a universally applicable strategy to improve editing precision and efficiency, and is effective in a mouse model of Rett syndrome in vivo.

中文翻译：

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G•U 摆动​​碱基对改善定点 RNA 碱基编辑


通过 RNA 碱基编辑提高基因校正的精度通常涉及到效率的权衡。我们发现使用G•U摆动碱基对是一种普遍适用的提高编辑精度和效率的策略，并且在体内Rett综合征小鼠模型中有效。