Use of alternative promoters by oncogene transcription factors increases as prostate tumours progress from benign to metastatic castration-resistant disease. This observation indicates that alternative promoter use intensifies the transcriptional effects of tumour-driving genes in prostate cancer.

Deep RNA-sequencing analysis of 274 biopsy samples of benign prostate tissue, localized prostate tumours and metastatic castration-resistant prostate cancer (mCRPC) showed that genes upregulated in localized prostate cancer or mCRPC and known oncogenes were at an increased likelihood of switching from a single alternative promoter to multiple ones in tumours. The opposite effect was observed for downregulated genes. Increased alternative promoter use was associated with upregulation of genes relevant to prostate cancer progression.

随着前列腺肿瘤从良性进展为转移性去势抵抗性疾病，癌基因转录因子对替代启动子的使用增加。这一观察结果表明，替代启动子的使用增强了前列腺癌中肿瘤驱动基因的转录效应。

对良性前列腺组织、局限性前列腺肿瘤和转移性去势抵抗性前列腺癌 (mCRPC) 的 274 个活检样本进行的深度 RNA 测序分析表明，局限性前列腺癌或 mCRPC 中上调的基因以及已知的癌基因从单一癌基因转变的可能性增加。肿瘤中多个启动子的替代启动子。对于下调基因观察到相反的效果。替代启动子使用的增加与前列腺癌进展相关基因的上调有关。