Recent advances in post Ugi-4CR dearomatizations for constructing spiro heterocycles,Organic Chemistry Frontiers

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Recent advances in post Ugi-4CR dearomatizations for constructing spiro heterocycles
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2024-07-12 , DOI: 10.1039/d4qo01060d
Xiao Tang ₁ , Qianqian Tao ₁ , Liangliang Song _{2,

3} , Erik V. Van der Eycken _{4,

5}

Affiliation

The Ugi reaction has obtained broad interest due to mild reaction conditions and high variability. The Ugi adducts provide myriad opportunities for post-transformations, leading to heterocycles, bioactive molecules, macrocycles, polymers, natural products and drugs. Recently, dearomatization strategies have been employed in post-Ugi transformations. Through transition metal catalysis and metal-free methods, different kinds of three dimensional complex molecules are formed in an atom- and step-economic manner. This review summarizes recent advances in the combination of the Ugi-4CR and dearomatization strategies for the synthesis of spirocycles.

中文翻译：

Ugi-4CR后脱芳构化构建螺杂环的最新进展

Ugi反应由于温和的反应条件和高度的可变性而引起了广泛的兴趣。 Ugi 加合物为后转化提供了无数的机会，产生杂环、生物活性分子、大环、聚合物、天然产物和药物。最近，脱芳构化策略已被应用于后 Ugi 转化中。通过过渡金属催化和无金属方法，以原子和步骤经济的方式形成不同种类的三维复杂分子。本综述总结了 Ugi-4CR 和脱芳构化策略相结合来合成螺环的最新进展。

更新日期：2024-07-17

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