Development of a Fluorescent Probe with High Selectivity based on Thiol-ene Click Nucleophilic Cascade Reactions for Delving into the Action Mechanism of Serotonin in Depression,Angewandte Chemie International Edition

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Development of a Fluorescent Probe with High Selectivity based on Thiol-ene Click Nucleophilic Cascade Reactions for Delving into the Action Mechanism of Serotonin in Depression
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-07-12 , DOI: 10.1002/anie.202407308
Lizhou Yue ₁ , Huawei Huang ₂ , Weiying Lin ₃

Affiliation

How to achieve rapid and accurate detection of serotonin in organisms is a key question in studying the pathogenesis of psychiatric disorders such as depression. To study the action mechanism of serotonin, we have developed a highly selective molecular probe based on thiol-ene click cascade nucleophilic reactions that enables real-time imaging of brain tissues in depression.

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