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Obesity-enriched gut microbe degrades myo-inositol and promotes lipid absorption
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2024-07-11 , DOI: 10.1016/j.chom.2024.06.012 Chao Wu 1 , Fangming Yang 2 , Huanzi Zhong 2 , Jie Hong 1 , Huibin Lin 1 , Mingxi Zong 1 , Huahui Ren 2 , Shaoqian Zhao 1 , Yufei Chen 1 , Zhun Shi 2 , Xingyu Wang 1 , Juan Shen 3 , Qiaoling Wang 1 , Mengshan Ni 1 , Banru Chen 1 , Zhongle Cai 1 , Minchun Zhang 1 , Zhiwen Cao 1 , Kui Wu 4 , Aibo Gao 1 , Junhua Li 3 , Cong Liu 3 , Minfeng Xiao 3 , Yan Li 3 , Juan Shi 1 , Yifei Zhang 1 , Xun Xu 3 , Weiqiong Gu 1 , Yufang Bi 1 , Guang Ning 1 , Weiqing Wang 1 , Jiqiu Wang 1 , Ruixin Liu 1
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2024-07-11 , DOI: 10.1016/j.chom.2024.06.012 Chao Wu 1 , Fangming Yang 2 , Huanzi Zhong 2 , Jie Hong 1 , Huibin Lin 1 , Mingxi Zong 1 , Huahui Ren 2 , Shaoqian Zhao 1 , Yufei Chen 1 , Zhun Shi 2 , Xingyu Wang 1 , Juan Shen 3 , Qiaoling Wang 1 , Mengshan Ni 1 , Banru Chen 1 , Zhongle Cai 1 , Minchun Zhang 1 , Zhiwen Cao 1 , Kui Wu 4 , Aibo Gao 1 , Junhua Li 3 , Cong Liu 3 , Minfeng Xiao 3 , Yan Li 3 , Juan Shi 1 , Yifei Zhang 1 , Xun Xu 3 , Weiqiong Gu 1 , Yufang Bi 1 , Guang Ning 1 , Weiqing Wang 1 , Jiqiu Wang 1 , Ruixin Liu 1
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Numerous studies have reported critical roles for the gut microbiota in obesity. However, the specific microbes that causally contribute to obesity and the underlying mechanisms remain undetermined. Here, we conducted shotgun metagenomic sequencing in a Chinese cohort of 631 obese subjects and 374 normal-weight controls and identified a -dominated, enterotype-like cluster enriched in obese subjects. Among this cohort, the presence of and polygenic risk exhibited an additive impact on obesity. possessed genes for -inositol degradation, as demonstrated and , and the addition of -inositol effectively inhibited fatty acid absorption in intestinal organoids. Furthermore, mice colonized with or heterologously expressing the -inositol-degrading iolG gene exhibited enhanced intestinal lipid absorption, thereby leading to obesity. Altogether, our findings uncover roles for as a -inositol degrader that enhances lipid absorption and obesity, suggesting potential strategies for future obesity management.
更新日期：2024-07-11
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