Anxiety is highly prevalent in Alzheimer's disease (AD), correlating with CSF/PET biomarkers and disease progression. Relationships to plasma biomarkers are unclear. Herein, we compare levels of plasma biomarkers in research participants with and without anxiety at cognitively normal, mild cognitive impairment, and AD dementia stages. We observed significantly higher plasma tau/Aβ42 ratio in AD participants with anxiety versus those without, but did not observe differences at other stages or plasma biomarkers. No such relationships were evident with depression. These results support a unique pathophysiological relationship between anxiety and AD that can be reflected in plasma biomarkers, suggestive of heightened neurodegeneration.

中文翻译：

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焦虑与阿尔茨海默病血浆生物标志物水平之间的关系


焦虑在阿尔茨海默病 (AD) 中非常普遍，与 CSF/PET 生物标志物和疾病进展相关。与血浆生物标志物的关系尚不清楚。在此，我们比较了认知正常、轻度认知障碍和 AD 痴呆阶段有焦虑和无焦虑的研究参与者的血浆生物标志物水平。我们观察到患有焦虑症的 AD 参与者的血浆 tau/Aβ42 比率显着高于没有焦虑症的参与者，但没有观察到其他阶段或血浆生物标志物的差异。抑郁症没有明显的这种关系。这些结果支持焦虑和 AD 之间独特的病理生理学关系，这种关系可以反映在血浆生物标志物中，表明神经退行性加剧。