Polar Lipids Supplementation Enhances Basal Excitatory Synaptic Transmission in Primary Cortical Neuron,Molecular Nutrition & Food Research

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Polar Lipids Supplementation Enhances Basal Excitatory Synaptic Transmission in Primary Cortical Neuron
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-07-10 , DOI: 10.1002/mnfr.202300883
Xin Yi Yeo _{1,

2} , Dao Tam ₃ , Yunju Jo ₄ , Jung Eun Kim ₅ , Dongryeol Ryu _{3,

4} , Jia Pei Chan ₆ , Sangyong Jung _{1,

7,

8}

Affiliation

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 61 Biopolis Drive, Proteos, Singapore, 138673, Republic of Singapore.
Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 9, Singapore, 119228, Republic of Singapore.
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea.
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of Korea.
Department of Food Science & Technology, Faculty of Science, National University of Singapore, S14 Level 6, Science Drive 2, Singapore, 117542, Republic of Singapore.
Research and Development Department, Abbott Nutrition, 3300 Stelzer Road, RP3-2, Columbus, Ohio, 43219, USA.
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 2 Medical Drive, MD9, Singapore, 117593, Republic of Singapore.
Department of Medical Science, College of Medicine, CHA University, CHA Bio Complex, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi-do, 13488, Republic of Korea.

Polar lipids, such as gangliosides and phospholipids, are fundamental structural components that play critical roles in the development and maturation of neurons in the brain. Recent evidence has demonstrated that dietary intakes of polar lipids in early life are associated with improved cognitive outcomes during infancy and adolescence. However, the specific mechanisms through which these lipids impact cognition remain unclear.

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