Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion,ACS Central Science

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Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion
ACS Central Science ( IF 12.7 ) Pub Date : 2016-10-27 00:00:00 , DOI: 10.1021/acscentsci.6b00272
Alois Fürstner ₁

Affiliation

The current status of homogeneous iron catalysis in organic chemistry is contemplated, as are the reasons why this particular research area only recently starts challenging the enduring dominance of the late and mostly noble metals over the field. Centered in the middle of the d-block and able to support formal oxidation states ranging from −II to +VI, iron catalysts hold the promise of being able to encompass organic synthesis at large. They are expected to serve reductive as well as oxidative regimes, can emulate “noble tasks”, but are also able to adopt “early” transition metal character. Since a comprehensive coverage of this multidimensional agenda is beyond the scope of an Outlook anyway, emphasis is laid in this article on the analysis of the factors that perhaps allow one to control the multifarious chemical nature of this earth-abundant metal. The challenges are significant, not least at the analytical frontier; their mastery mandates a mindset that differs from the routines that most organic chemists interested in (noble metal) catalysis tend to cultivate. This aspect notwithstanding, it is safe to predict that homogeneous iron catalysis bears the chance to enable a responsible paradigm for chemical synthesis and a sustained catalyst economy, while potentially providing substantial economic advantages. This promise will spur the systematic and in-depth investigations that it takes to upgrade this research area to strategy-level status in organic chemistry and beyond.

中文翻译：

有机合成中的铁催化：对如何使这种贱金属成为多任务冠军的关键评估

均相铁催化在有机化学中的现状值得关注，这也是这个特定研究领域最近才开始挑战晚期贵金属在该领域的持久主导地位的原因。铁催化剂位于 d 区中间，能够支持从 -II 到 +VI 范围内的形式氧化态，有望涵盖整个有机合成。它们有望发挥还原和氧化作用，可以模仿“崇高的任务”，但也能够采用“早期”过渡金属特性。由于对这一多维议程的全面覆盖无论如何都超出了展望的范围，因此本文的重点是分析可能允许人们控制这种地球上丰富的金属的多种化学性质的因素。挑战是巨大的，尤其是在分析前沿；他们的掌握要求一种不同于大多数对（贵金属）催化感兴趣的有机化学家倾向于培养的常规的思维方式。尽管如此，可以安全地预测均相铁催化有机会为化学合成和持续的催化剂经济提供可靠的范例，同时可能提供巨大的经济优势。这一承诺将促进系统性和深入的研究，将这一研究领域提升到有机化学及其他领域的战略水平。

更新日期：2016-10-27

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