Highly efficient esterification of carboxylic acids with O–H nucleophiles through acid/iodide cooperative catalysis,Organic & Biomolecular Chemistry

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Highly efficient esterification of carboxylic acids with O–H nucleophiles through acid/iodide cooperative catalysis
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2024-07-10 , DOI: 10.1039/d4ob00910j
Dongxu Zuo ₁ , Xiong Xiao ₁ , Xinyue Ma ₁ , Peng Nie ₂ , Long Liu ₁ , Tieqiao Chen ₁

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The esterification of carboxylic acids is an important reaction for preparing esters which find wide applications in various research fields. In this manuscript, we report an acid/iodide cooperative catalytic method which enables highly efficient esterification of carboxylic acids with a wide range of equivalent O–H nucleophiles including both alcohols and weak nucleophilic phenols. Under the reaction conditions, both aromatic and aliphatic carboxylic acids including those bearing functional groups work well, furnishing the corresponding esters in good to high yields. Moreover, this reaction is scalable and applicable to the modification of bioactive molecules. These results demonstrate the synthetic value of this new reaction in organic synthesis.

中文翻译：

通过酸/碘化物协同催化，羧酸与 O-H 亲核试剂高效酯化

羧酸的酯化是制备酯的重要反应，在各个研究领域都有广泛的应用。在这篇手稿中，我们报道了一种酸/碘化物协同催化方法，该方法能够使羧酸与各种等价的O-H亲核试剂（包括醇和弱亲核酚）进行高效酯化。在反应条件下，芳香族和脂肪族羧酸（包括那些带有官能团的羧酸）都能很好地发挥作用，以良好到高的收率提供相应的酯。此外，该反应具有可扩展性，适用于生物活性分子的修饰。这些结果证明了这种新反应在有机合成中的合成价值。

更新日期：2024-07-10

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