N-Phenyl-2-Pyridone-Derived Endoperoxide Suppressing both Lung Cancer and Idiopathic Pulmonary Fibrosis Progression by Three-Pronged Action**,Angewandte Chemie International Edition

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N-Phenyl-2-Pyridone-Derived Endoperoxide Suppressing both Lung Cancer and Idiopathic Pulmonary Fibrosis Progression by Three-Pronged Action**
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-07-09 , DOI: 10.1002/anie.202408473
Lei Wang ₁ , Hao Wu ₁ , Ziang Liu ₁ , Rensong Sun ₁ , Yanping Li ₁ , Yu Si ₁ , Yun Nie ₁ , Yuan Qiao ₁ , Xiao Qian ₁ , Shengli Zhang ₁ , Guangzhe Li ₁ , Wen Sun ₁ , Yue Pan ₁ , Engin U Akkaya ₁

Affiliation

An endoperoxide compound (E5) spontaneously deliver three active agents and target multiple mechanisms for treating non-small cell lung cancer and idiopathic pulmonary fibrosis. Many lines of evidence reveal the therapeutic efficacy of singlet oxygen and 3-methyl-N-phenyl-2-pyridone. In addition, triplet oxygen could downregulate HIF-1α and relieve tumor hypoxia which is an important issue in many refractory cancers.

中文翻译：

N-苯基-2-吡啶酮衍生的内过氧化物通过三管齐下抑制肺癌和特发性肺纤维化进展**

内过氧化物化合物 ( E5 ) 自发地递送三种活性剂并针对治疗非小细胞肺癌和特发性肺纤维化的多种机制。许多证据揭示了单线态氧和 3-甲基-N-苯基-2-吡啶酮的治疗功效。此外，三线态氧可以下调 HIF-1α 并缓解肿瘤缺氧，这是许多难治性癌症的一个重要问题。

更新日期：2024-07-09

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