The pros and confs of IL-18 activation,Immunity

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The pros and confs of IL-18 activation
Immunity ( IF 25.5 ) Pub Date : 2024-07-09 , DOI: 10.1016/j.immuni.2024.06.006
Danielle M Clancy ₁ , Julie Andries ₁ , Savvas N Savvides ₁

Affiliation

Interleukin-1 (IL-1) family cytokines are key immunological regulators that achieve their signaling prowess after post-translational proteolytic processing. In this issue of Immunity, Dong et al. reveal the structural consequences of this process on proinflammatory IL-18, demonstrating that pro-IL-18 and mature IL-18 are structurally distinct.

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