The physiological and pathological roles of RNA modifications in T cells,Cell Chemical Biology

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The physiological and pathological roles of RNA modifications in T cells
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2024-07-09 , DOI: 10.1016/j.chembiol.2024.06.003
Yu Deng ₁ , Jing Zhou ₁ , Hua-Bing Li ₂

Affiliation

RNA molecules undergo dynamic chemical modifications in response to various external or cellular stimuli. Some of those modifications have been demonstrated to post-transcriptionally modulate the RNA transcription, localization, stability, translation, and degradation, ultimately tuning the fate decisions and function of mammalian cells, particularly T cells. As a crucial part of adaptive immunity, T cells play fundamental roles in defending against infections and tumor cells. Recent findings have illuminated the importance of RNA modifications in modulating T cell survival, proliferation, differentiation, and functional activities. Therefore, understanding the epi-transcriptomic control of T cell biology enables a potential avenue for manipulating T cell immunity. This review aims to elucidate the physiological and pathological roles of internal RNA modifications in T cell development, differentiation, and functionality drawn from current literature, with the goal of inspiring new insights for future investigations and providing novel prospects for T cell-based immunotherapy.

中文翻译：

T细胞中RNA修饰的生理和病理作用

RNA 分子响应各种外部或细胞刺激而经历动态化学修饰。其中一些修饰已被证明可以在转录后调节 RNA 转录、定位、稳定性、翻译和降解，最终调整哺乳动物细胞（尤其是 T 细胞）的命运决定和功能。作为适应性免疫的重要组成部分，T 细胞在防御感染和肿瘤细胞方面发挥着重要作用。最近的研究结果阐明了 RNA 修饰在调节 T 细胞存活、增殖、分化和功能活动中的重要性。因此，了解 T 细胞生物学的表观转录组控制为操纵 T 细胞免疫提供了潜在途径。本综述旨在从现有文献中阐明内部 RNA 修饰在 T 细胞发育、分化和功能中的生理和病理作用，旨在为未来的研究激发新的见解，并为基于 T 细胞的免疫治疗提供新的前景。

更新日期：2024-07-09

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