Tissue regeneration after damage is generally thought to involve the mobilization of adult stem cells that divide and differentiate into progressively specialized progeny. However, recent studies indicate that tissue regeneration can be accompanied by reversion to a fetal-like state. During this process, cells at the injury site reactivate programs that operate during fetal development but are typically absent in adult homeostasis. Here, we summarize our current understanding of the molecular signals and epigenetic mediators that orchestrate “fetal-like reversion” during intestinal regeneration. We also explore evidence for this phenomenon in other organs and species and highlight open questions that merit future examination.

中文翻译：

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在肠道内外再生过程中激活类似胎儿的分子程序


通常认为损伤后的组织再生涉及成体干细胞的动员，这些干细胞分裂并分化为逐渐特化的后代。然而，最近的研究表明，组织再生可能伴随着恢复到胎儿样状态。在此过程中，损伤部位的细胞重新激活在胎儿发育期间运行但在成人体内平衡中通常不存在的程序。在这里，我们总结了目前对肠道再生过程中协调“胎儿样逆转”的分子信号和表观遗传介质的理解。我们还在其他器官和物种中探索这种现象的证据，并强调值得未来研究的悬而未决的问题。