In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and antigen-specific CD4⁺ and CD8⁺ T cells. This interaction reprograms tumor-specific CD8⁺ T cells to exert potent effector functions and eradicate established solid tumors.

中文翻译：

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免疫细胞三联体重新编程耗尽的 CD8+ T 细胞以有效消除肿瘤

在本期《癌细胞》中，Espinosa-Carrasco等人。研究表明，癌症免疫疗法的功效取决于抗原呈递细胞与抗原特异性 CD4 ⁺和 CD8 ⁺ T 细胞之间瘤内免疫三联体的形成。这种相互作用对肿瘤特异性 CD8 ⁺ T 细胞进行重新编程，以发挥有效的效应功能并根除已形成的实体瘤。