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Immune cell triads reprogram exhausted CD8+ T cells for effective tumor elimination
Cancer Cell ( IF 48.8 ) Pub Date : 2024-07-08 , DOI: 10.1016/j.ccell.2024.06.010 Veronica Lise 1 , Ines Malenica 1 , Rahul Roychoudhuri 2 , Enrico Lugli 1
中文翻译:
免疫细胞三联体重新编程耗尽的 CD8+ T 细胞以有效消除肿瘤
更新日期:2024-07-08
Cancer Cell ( IF 48.8 ) Pub Date : 2024-07-08 , DOI: 10.1016/j.ccell.2024.06.010 Veronica Lise 1 , Ines Malenica 1 , Rahul Roychoudhuri 2 , Enrico Lugli 1
Affiliation
In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and antigen-specific CD4+ and CD8+ T cells. This interaction reprograms tumor-specific CD8+ T cells to exert potent effector functions and eradicate established solid tumors.
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
免疫细胞三联体重新编程耗尽的 CD8+ T 细胞以有效消除肿瘤
在本期《癌细胞》中,Espinosa-Carrasco等人。研究表明,癌症免疫疗法的功效取决于抗原呈递细胞与抗原特异性 CD4 +和 CD8 + T 细胞之间瘤内免疫三联体的形成。这种相互作用对肿瘤特异性 CD8 + T 细胞进行重新编程,以发挥有效的效应功能并根除已形成的实体瘤。