A new study shows that transplantation of bone marrow from young mice can reduce amyloid pathology and ameliorate cognitive deficits in a mouse model of Alzheimer disease (AD). Aged (9-month-old) APP/PS1 mice received bone marrow from 2-month-old or 9-month-old APP/PS1 mice. The young bone marrow transplants led to reductions in cerebral amyloid plaque burden (attributed to increased amyloid-β clearance from the brain by blood monocytes) and improved performance on behavioural tests. The findings warrant further exploration of immune system rejuvenation to treat AD.

中文翻译：

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免疫复兴——一种潜在的 AD 疗法

一项新的研究表明，年轻小鼠的骨髓移植可以减少阿尔茨海默病（AD）小鼠模型中的淀粉样蛋白病理并改善认知缺陷。年老（9 个月大）的APP/PS1小鼠接受 2 个月或 9 个月大的APP/PS1小鼠的骨髓。年轻的骨髓移植导致大脑淀粉样蛋白斑块负担减少（归因于血液单核细胞从大脑中清除淀粉样蛋白-β的增加）并提高了行为测试的表现。这些发现值得进一步探索免疫系统复兴来治疗 AD。