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Maternal asthma during pregnancy and risks of allergy and asthma in progeny: A systematic review and meta‐analysis
BJOG: An International Journal of Obstetrics & Gynaecology ( IF 4.7 ) Pub Date : 2024-07-08 , DOI: 10.1111/1471-0528.17900
Andrea J Roff 1, 2 , Joshua L Robinson 1, 3 , Sarah J Hammond 1, 4 , Jana Bednarz 5, 6 , Andrew Tai 1, 7 , Vicki L Clifton 8 , Janna L Morrison 4 , Kathryn L Gatford 1, 2
Affiliation  

BackgroundClinical and preclinical evidence indicate that in utero maternal asthma exposure increases progeny asthma risk. Whether maternal asthma also increases the risks of progeny allergy is unclear.ObjectivesTo synthesise the available evidence on the relationship between in utero exposure to maternal asthma and postnatal asthma, wheezing and allergic diseases (Prospero: CRD42020201538).Search StrategyWe systematically searched MEDLINE [PubMed], Embase [Ovid], Web of Science, Informit Health, the Cochrane Library, CINAHL [EBSCOhost], MedNar [Deep Web Technologies], ProQuest Theses and Dissertations, Scopus [Elsevier] and Trove, to the end of 2023.Selection CriteriaStudies reporting asthma, wheeze and/or allergic disease in progeny of women with and without asthma or with asthma classified by control, exacerbation or severity.Data Collection and AnalysisDouble screening, selection, data extraction and quality assessment were performed, using Joanna Briggs Institute (JBI) scoring.Main ResultsOf 134 non‐overlapping studies, 127 were included in ≥1 meta‐analysis. Maternal asthma ever was associated with greater risks of asthma (65 studies, risk ratio [95% confidence interval] 1.76 [1.57–1.96]), wheeze (35 studies, 1.59 [1.52–1.66]), food allergy (5 studies, 1.32 [1.23–1.40]), allergic rhinitis (7 studies, 1.18 [1.06–1.31]) and allergic dermatitis (14 studies, 1.17 [1.11–1.23]) ever in progeny. Asthma during the pregnancy, more severe, and uncontrolled maternal asthma were each associated with greater risks of progeny asthma.ConclusionsChildren of mothers with asthma are at increased risk for the development of allergic diseases. Whether improved maternal asthma control reduces risks of child allergy as well as asthma requires further investigation.

中文翻译:


孕期母亲哮喘以及后代过敏和哮喘的风险:系统评价和荟萃分析



背景临床和临床前证据表明,子宫内母亲哮喘暴露会增加后代哮喘风险。孕产妇哮喘是否也会增加后代过敏的风险尚不清楚。目的综合关于子宫内暴露于孕产妇哮喘与产后哮喘、喘息和过敏性疾病之间关系的现有证据(Prospero:CRD42020201538)。搜索策略我们系统地搜索了 MEDLINE [PubMed] 、Embase [Ovid]、Web of Science、Informit Health、Cochrane 图书馆、CINAHL [EBSCOhost]、MedNar [深网技术]、ProQuest 论文和论文、Scopus [Elsevier] 和 Trove,截至 2023 年底。选择标准研究报告患有或不患有哮喘或患有按控制、恶化或严重程度分类的哮喘的妇女的后代中的哮喘、喘息和/或过敏性疾病。数据收集和分析使用乔安娜布里格斯研究所(JBI)进行了双重筛选、选择、数据提取和质量评估主要结果 在 134 项非重叠研究中,127 项纳入≥1 项荟萃分析。母亲哮喘曾与哮喘(65 项研究,风险比 [95% 置信区间] 1.76 [1.57–1.96])、喘息(35 项研究,1.59 [1.52–1.66])、食物过敏(5 项研究,1.32)的风险相关[1.23–1.40])、过敏性鼻炎(7项研究,1.18[1.06–1.31])和过敏性皮炎(14项研究,1.17[1.11–1.23])曾在后代中出现。怀孕期间的哮喘、更严重的和不受控制的母亲哮喘均与子代哮喘的更大风险相关。结论患有哮喘的母亲的孩子患过敏性疾病的风险增加。改善母亲哮喘控制是否可以降低儿童过敏和哮喘的风险需要进一步研究。
更新日期:2024-07-08
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