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Treatment of chronic kidney disease in older populations
Nature Reviews Nephrology ( IF 28.6 ) Pub Date : 2024-07-08 , DOI: 10.1038/s41581-024-00854-w
Seiji Kishi 1 , Hiroyuki Kadoya 2 , Naoki Kashihara 3, 4
Affiliation  

As the world population ages, an expected increase in the prevalence of chronic kidney disease (CKD) among older individuals will pose a considerable challenge for health care systems in terms of resource allocation for disease management. Treatment strategies for older patients with CKD should ideally align with those applied to the general population, focusing on minimizing cardiovascular events and reducing the risk of progression to kidney failure. Emerging therapies, such as SGLT-2 inhibitors and GLP-1 receptor agonists, hold promise for the effective management of CKD in older individuals. In addition, non-pharmacological interventions such as nutritional and exercise therapies have a crucial role. These interventions enhance the effects of pharmacotherapy and, importantly, contribute to the maintenance of cognitive function and overall quality of life. Various factors beyond age and cognitive function must be taken into account when considering kidney replacement therapy for patients with kidney failure. Importantly, all treatment options, including dialysis, transplantation and conservative management approaches, should be tailored to the individual through patient-centred decision-making. The dynamic integration of digital technologies into medical practice has the potential to transform the management of CKD in the aging population.



中文翻译:


老年人慢性肾病的治疗



随着世界人口老龄化,老年人慢性肾病(CKD)患病率的预期上升将对医疗保健系统在疾病管理资源分配方面构成相当大的挑战。老年 CKD 患者的治疗策略最好与普通人群的治疗策略保持一致,重点是尽量减少心血管事件并降低进展为肾衰竭的风险。 SGLT-2 抑制剂和 GLP-1 受体激动剂等新兴疗法有望有效治疗老年人的 CKD。此外,营养和运动疗法等非药物干预也发挥着至关重要的作用。这些干预措施增强了药物治疗的效果,重要的是,有助于维持认知功能和整体生活质量。在考虑对肾衰竭患者进行肾脏替代治疗时,必须考虑年龄和认知功能以外的各种因素。重要的是,所有治疗方案,包括透析、移植和保守治疗方法,都应通过以患者为中心的决策来针对个人情况进行定制。数字技术与医疗实践的动态整合有可能改变老龄化人口中 CKD 的管理。

更新日期:2024-07-08
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