A supercritical CO assisted process was used to perform a comparative study between liposomes and niosomes. Process operating conditions were fixed at 100 bar and 40 °C, and the produced vesicles were characterized in terms of mean diameter, size distribution, ζ-potential, and stability over time. Mean diameters of liposomes and niosomes were similar (130 ± 37 nm for liposomes and 141 ± 36 nm for niosomes) and both systems were stable after 1 month from production. Ascorbic acid (AA) was loaded in both kinds of formulation. AA encapsulation efficiency was equal to 92 % and 99 % for liposomes and niosomes, respectively, and DPPH-activity was larger than 90 % in both vesicular systems. Drug release tests revealed that AA was released in 120 min and 240 min from liposomes and niosomes, respectively, due to a different compactness of the vesicle bilayer.

中文翻译：

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通过超临界 CO2 辅助工艺生产局部应用的脂质体和脂质体：比较研究


使用超临界 CO 辅助过程对脂质体和脂质体进行比较研究。工艺操作条件固定在 100 bar 和 40 °C，并根据平均直径、尺寸分布、ζ 电位和随时间的稳定性对产生的囊泡进行表征。脂质体和类脂质体的平均直径相似（脂质体为 130 ± 37 nm，类脂质体为 141 ± 36 nm），并且两种系统在生产 1 个月后均保持稳定。两种配方中均添加了抗坏血酸（AA）。脂质体和类脂质体的 AA 封装效率分别为 92% 和 99%，并且两个囊泡系统中的 DPPH 活性均大于 90%。药物释放测试表明，由于囊泡双层的致密性不同，AA 分别在 120 分钟和 240 分钟内从脂质体和类脂质体中释放。