polyphenolic natural extracts have several benefits for human health. Due to their instability and reduced shelf-life, these extracts are usually encapsulated. This work analyzed the supercritical emulsion extraction (SEE) process for the production of polymeric nanoparticles loaded with . polyphenolic extracts. The objective of this work was to evaluate a powdered encapsulation system to overcome the drawbacks of liquid systems, which are those mainly used for microalgae extract stabilization. An optimization study was performed investigating different process parameters and comparing the obtained particles in terms of particle size distribution, morphology, and encapsulation efficiency. The process permitted the successfull production of loaded polymeric nanoparticles with an encapsulation efficiency up to 74 % in the best operating conditions. The SEE process allowed a better control of morphology and particle size distribution of the nanometric particles operating in a continuous mode.

中文翻译：

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使用超临界乳液工艺封装钝顶节旋藻多酚提取物


多酚天然提取物对人类健康有多种好处。由于它们的不稳定性和保质期缩短，这些提取物通常被封装。这项工作分析了用于生产负载聚合物纳米颗粒的超临界乳液萃取 (SEE) 工艺。多酚提取物。这项工作的目的是评估粉末封装系统，以克服液体系统的缺点，液体系统主要用于稳定微藻提取物。进行了优化研究，研究了不同的工艺参数，并比较了所得颗粒的粒径分布、形态和包封效率。该工艺可成功生产负载聚合物纳米粒子，在最佳操作条件下封装效率高达 74%。 SEE 工艺可以更好地控制以连续模式运行的纳米粒子的形态和粒度分布。