Gastric cancer significantly contributes to global cancer mortality, often leading to inoperable stages and high recurrence rates post-surgery. Elevated levels of G-17 and G-gly have been identified as potential risk factors, particularly in patients with duodenal ulcers. This study introduces an innovative D-shaped grinding long-period fiber grating sensor (D-LLPFGs) designed for non-invasive detection of the gastrin G-17 antigen, employing a layer-by-layer chemical self-assembly to bond G-17 antibodies onto the fiber surface through hydrogen bonding. The D-LLPFGs sensor demonstrated significant spectral shifts within 1 min of antigen-antibody interaction, highlighting its rapid detection capability. At an optimized antibody concentration of 4 μg/ml, antigen testing across different concentrations (10, 12.5, 20, 50 μg/ml) showed peak changes at 12.5 μg/ml antigen, with a 1.186 nm shift and 0.503 dB loss. The sensor exhibited a wavelength sensitivity of 0.095 nm/μg/ml, indicating its high sensitivity and potential in gastric cancer classification, diagnosis, and treatment. This research concludes that the D-shaped fiber sensor is an effective and sensitive tool for detecting G-17 antigen levels, presenting a significant advancement in non-invasive gastric cancer diagnosis. Its quick response time and high sensitivity highlight its potential for broad biomedical applications, offering a new avenue for early cancer detection and improving patient prognosis. The success of this study opens the door to further exploration and implementation of fiber optic sensors in clinical settings, marking a significant step forward in the fight against gastric cancer.

中文翻译：

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层层涂覆D形磨削长周期光纤光栅传感器检测胃癌生物标志物的途径


胃癌对全球癌症死亡率有显着影响，通常导致无法手术阶段和术后高复发率。 G-17 和 G-gly 水平升高已被确定为潜在的危险因素，特别是对于十二指肠溃疡患者。本研究介绍了一种创新的D形磨削长周期光纤光栅传感器（D-LLPFGs），专为非侵入性检测胃泌素G-17抗原而设计，采用逐层化学自组装方式键合G-17抗体通过氢键结合到纤维表面。 D-LLPFGs 传感器在抗原抗体相互作用的 1 分钟内表现出显着的光谱变化，凸显了其快速检测能力。在 4 μg/ml 的优化抗体浓度下，不同浓度（10、12.5、20、50 μg/ml）的抗原测试显示 12.5 μg/ml 抗原处出现峰值变化，位移为 1.186 nm，损失为 0.503 dB。该传感器的波长灵敏度为0.095 nm/μg/ml，表明其在胃癌分类、诊断和治疗方面具有高灵敏度和潜力。这项研究得出的结论是，D 形光纤传感器是检测 G-17 抗原水平的有效且灵敏的工具，为非侵入性胃癌诊断带来了重大进步。其快速响应时间和高灵敏度凸显了其广泛的生物医学应用潜力，为早期癌症检测和改善患者预后提供了新途径。这项研究的成功为进一步探索和在临床环境中应用光纤传感器打开了大门，标志着对抗胃癌的重大一步。