A research synthesis of humans, animals, and environmental compartments exposed to PFAS: A systematic evidence map and bibliometric analysis of secondary literature,Environment International

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A research synthesis of humans, animals, and environmental compartments exposed to PFAS: A systematic evidence map and bibliometric analysis of secondary literature
Environment International ( IF 10.3 ) Pub Date : 2024-06-30 , DOI: 10.1016/j.envint.2024.108860
Lorenzo Ricolfi ₁ , Catharina Vendl ₂ , Jennifer Bräunig ₃ , Matthew D Taylor ₄ , Daniel Hesselson ₅ , G Gregory Neely ₆ , Malgorzata Lagisz ₇ , Shinichi Nakagawa ₇

Affiliation

Evolution and Ecology Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales Sydney, Sydney, Australia.
Evolution and Ecology Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales Sydney, Sydney, Australia; Dauphin Island Sea Lab, Dauphin Island, Al, USA.
Queensland Alliance for Environmental Health Sciences, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, Australia; NSW Department of Climate Change, Energy, the Environment and Water, Environment Protection Science Branch, Sydney, Australia.
Evolution and Ecology Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales Sydney, Sydney, Australia; Queensland Alliance for Environmental Health Sciences, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, Australia; Port Stephens Fisheries Institute, New South Wales Department of Primary Industries, Nelson Bay, Australia.
Centenary Institute and Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, Australia.
Evolution and Ecology Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales Sydney, Sydney, Australia; Theoretical Sciences Visiting Program, Okinawa Institute of Science and Technology Graduate University, Onna, Japan.

Per- and polyfluoroalkyl substances (PFAS) are a class of widely used anthropogenic chemicals. Concerns regarding their persistence and potential adverse effects have led to multiple secondary research publications. Here, we aim to assess the resulting evidence base in the systematic secondary literature by examining research gaps, evaluating the quality of reviews, and exploring interdisciplinary connections. This study employed a systematic evidence-mapping approach to assess the secondary literature on the biological, environmental, and medical aspects of exposure to 35 fluorinated compounds. The inclusion criteria encompassed systematic reviews published in peer-reviewed journals, pre-prints, and theses. Comprehensive searches across electronic databases and grey literature identified relevant reviews. Data extraction and synthesis involved mapping literature content and narrative descriptions. We employed a modified version of the AMSTAR2 checklist to evaluate the methodological rigour of the reviews. A bibliometric data analysis uncovered patterns and trends in the academic literature. A research protocol for this study was previously pre-registered () and published (Vendl et al., Environment International 158 (2022) 106973). The database is freely accessible through the interactive and user-friendly web application of this systematic evidence map at . Our map includes a total of 175 systematic reviews. Over the years, there has been a steady increase in the annual number of publications, with a notable surge in 2021. Most reviews focused on human exposure, whereas environmental and animal-related reviews were fewer and often lacked a rigorous systematic approach to literature search and screening. Review outcomes were predominantly associated with human health, particularly with reproductive and children’s developmental health. Animal reviews primarily focused on studies conducted in controlled laboratory settings, and wildlife reviews were characterised by an over-representation of birds and fish species. Recent reviews increasingly incorporated quantitative synthesis methodologies. The methodological strengths of the reviews included detailed descriptions of study selection processes and disclosure of potential conflicts of interest. However, weaknesses were observed in the critical lack of detail in reporting methods. A bibliometric analysis revealed that the most productive authors collaborate within their own country, leading to limited and clustered international collaborations. In this overview of the available systematic secondary literature, we map literature content, assess reviews’ methodological quality, highlight data gaps, and draw research network clusters. We aim to facilitate literature reviews, guide future research initiatives, and enhance opportunities for cross-country collaboration. Furthermore, we discuss how this systematic evidence map and its publicly available database benefit scientists, regulatory agencies, and other stakeholders by providing access to current systematic secondary literature on PFAS exposure.

中文翻译：

对接触 PFAS 的人类、动物和环境区域的研究综合：系统证据图和二手文献的文献计量分析

全氟烷基物质和多氟烷基物质 (PFAS) 是一类广泛使用的人为化学品。对它们的持久性和潜在不利影响的担忧导致了多项二级研究出版物的发表。在这里，我们的目标是通过检查研究差距、评估评论质量和探索跨学科联系来评估系统二级文献中产生的证据基础。本研究采用系统证据映射方法来评估有关 35 种氟化化合物暴露的生物、环境和医学方面的二手文献。纳入标准包括在同行评审期刊、预印本和论文中发表的系统评论。对电子数据库和灰色文献的全面搜索确定了相关评论。数据提取和综合涉及绘制文献内容和叙述描述。我们采用了 AMSTAR2 检查表的修改版本来评估评审方法的严谨性。文献计量数据分析揭示了学术文献中的模式和趋势。本研究的研究方案先前已预先注册 () 并发布（Vendl 等人，Environment International 158 (2022) 106973）。该数据库可通过该系统证据图的交互式且用户友好的网络应用程序免费访问。我们的地图总共包含 175 条系统评论。多年来，每年的出版物数量稳步增长，2021 年出现显着激增。大多数评论关注人类暴露，而环境和动物相关评论较少，且往往缺乏严格的系统性文献检索方法和筛选。审查结果主要与人类健康有关，特别是与生殖和儿童发育健康有关。动物审查主要侧重于在受控实验室环境中进行的研究，而野生动物审查的特点是鸟类和鱼类物种代表性过高。最近的评论越来越多地纳入定量合成方法。审查的方法论优势包括对研究选择过程的详细描述和潜在利益冲突的披露。然而，我们也发现了报告方法严重缺乏细节的弱点。文献计量分析显示，最有生产力的作者在自己的国家内进行合作，导致国际合作有限且集中。在对现有系统性二级文献的概述中，我们绘制了文献内容图，评估了综述的方法论质量，突出了数据差距，并绘制了研究网络集群。我们的目标是促进文献综述，指导未来的研究计划，并增加跨国合作的机会。此外，我们还讨论了该系统证据图及其公开数据库如何通过提供有关 PFAS 暴露的当前系统二级文献来使科学家、监管机构和其他利益相关者受益。

更新日期：2024-06-30

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