Unveiling therapeutic potential: Adipose tissue-derived mesenchymal stem cells and their exosomes in the management of diabetes mellitus, wound healing, and chronic ulcers,BIOCHEMICAL PHARMACOLOGY

当前位置： X-MOL 学术 › Biochem. Pharmacol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Unveiling therapeutic potential: Adipose tissue-derived mesenchymal stem cells and their exosomes in the management of diabetes mellitus, wound healing, and chronic ulcers
BIOCHEMICAL PHARMACOLOGY ( IF 5.3 ) Pub Date : 2024-06-27 , DOI: 10.1016/j.bcp.2024.116399
Amirhossein Ahmadieh-Yazdi ₁ , Mahdieh Karimi ₁ , Elham Afkhami ₂ , Fatemeh Hajizadeh-Tafti ₁ , Fatemeh Kuchakzadeh ₃ , Piao Yang ₄ , Mohsen Sheykhhasan ₅

Affiliation

Diabetes mellitus (DM) is a pervasive global health issue with substantial morbidity and mortality, often resulting in secondary complications, including diabetic wounds (DWs). These wounds, arising from hyperglycemia, diabetic neuropathy, anemia, and ischemia, afflict approximately 15% of diabetic patients, with a considerable 25% at risk of lower limb amputations. The conventional approaches for chronic and diabetic wounds management involves utilizing various therapeutic substances and techniques, encompassing growth factors, skin substitutes and wound dressings. In parallel, emerging cell therapy approaches, notably involving adipose tissue-derived mesenchymal stem cells (ADMSCs), have demonstrated significant promise in addressing diabetes mellitus and its complications. ADMSCs play a pivotal role in wound repair, and their derived exosomes have garnered attention for their therapeutic potential. This review aimed to unravel the potential mechanisms and provide an updated overview of the role of ADMSCs and their exosomes in diabetes mellitus and its associated complications, with a specific focus on wound healing.

中文翻译：

揭示治疗潜力：脂肪组织来源的间充质干细胞及其外泌体在糖尿病、伤口愈合和慢性溃疡治疗中的应用

糖尿病（DM）是一个普遍的全球健康问题，发病率和死亡率很高，通常会导致继发性并发症，包括糖尿病伤口（DW）。这些由高血糖、糖尿病神经病变、贫血和缺血引起的伤口，折磨着大约 15% 的糖尿病患者，其中相当 25% 的人有下肢截肢的风险。慢性和糖尿病伤口管理的传统方法涉及利用各种治疗物质和技术，包括生长因子、皮肤替代品和伤口敷料。与此同时，新兴的细胞治疗方法，特别是涉及脂肪组织来源的间充质干细胞（ADMSC），在解决糖尿病及其并发症方面显示出巨大的前景。ADMSC 在伤口修复中起着关键作用，其衍生的外泌体因其治疗潜力而受到关注。本综述旨在揭示潜在机制，并对 ADMSC 及其外泌体在糖尿病及其相关并发症中的作用提供最新概述，特别关注伤口愈合。

更新日期：2024-06-27

点击分享查看原文

点击收藏

阅读更多本刊新发论文