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Effect of zamicastat on blood pressure and heart rate response to cold pressor test: A double-blind, randomized, placebo-controlled study in healthy subjects
British Journal of Clinical Pharmacology ( IF 3.1 ) Pub Date : 2024-07-06 , DOI: 10.1111/bcp.16167 Marlene Fonseca 1 , Cheila Ribeiro 2 , Guillermo Castilla-Fernández 2, 3 , Helena Gama 2 , Luís Magalhães 2 , Sara Carolina Henriques 1, 4 , Nuno Silva 1, 4 , Filipe Pinto 1 , Luís Almeida 1, 5, 6 , Patrício Soares-da-Silva 5, 6
British Journal of Clinical Pharmacology ( IF 3.1 ) Pub Date : 2024-07-06 , DOI: 10.1111/bcp.16167 Marlene Fonseca 1 , Cheila Ribeiro 2 , Guillermo Castilla-Fernández 2, 3 , Helena Gama 2 , Luís Magalhães 2 , Sara Carolina Henriques 1, 4 , Nuno Silva 1, 4 , Filipe Pinto 1 , Luís Almeida 1, 5, 6 , Patrício Soares-da-Silva 5, 6
Affiliation
Dopamine beta-hydroxylase (DβH) inhibitors, like zamicastat, hold promise for treating pulmonary arterial hypertension. This study aimed to validate the mechanism of action of zamicastat by studying its effect on the overdrive of the sympathetic nervous system (SNS).
中文翻译:
扎米卡司他对血压和心率对冷加压试验反应的影响:一项针对健康受试者的双盲、随机、安慰剂对照研究
多巴胺 β-羟化酶 (DβH) 抑制剂,如 zamicastat,有望治疗肺动脉高压。本研究旨在通过研究扎米卡司他对交感神经系统 (SNS) 超速驱动的影响来验证扎米卡司他的作用机制。
更新日期:2024-07-06
中文翻译:
扎米卡司他对血压和心率对冷加压试验反应的影响:一项针对健康受试者的双盲、随机、安慰剂对照研究
多巴胺 β-羟化酶 (DβH) 抑制剂,如 zamicastat,有望治疗肺动脉高压。本研究旨在通过研究扎米卡司他对交感神经系统 (SNS) 超速驱动的影响来验证扎米卡司他的作用机制。