OBJECTIVE To investigate associations of plasma glycated albumin (GA) concentrations in early and midpregnancy with gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND METHODS We measured GA concentrations using blood samples collected at 10–14 and 15–26 weeks’ gestation (GW) in 107 GDM case subjects and 214 control subjects from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Study. We performed generalized linear mixed-effect regression to test the mean GA difference between GDM case subjects and control subjects and conditional logistic regression to assess prospective associations between GA concentrations and GDM risk. RESULTS At 15–26 GW, mean GA was lower in GDM case subjects than control subjects (mean 11.90% [95% CI 6.42–32.76] vs. 12.46% [8.45–38.35], adjusted P value for difference = 0.004). Consistently, women with higher GA concentrations tended to have a lower GDM risk, although the associations were not statistically significant. CONCLUSIONS This study suggests that GA concentrations in midpregnancy might be lower in women who later develop GDM. Further studies are needed to identify the mechanism.

中文翻译：

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妊娠早期血浆糖化白蛋白和妊娠糖尿病：一项前瞻性纵向研究


目的探讨妊娠早期和中期血浆糖化白蛋白（GA）浓度与妊娠期糖尿病（GDM）风险的关系。研究设计和方法 我们使用来自尤尼斯·肯尼迪·施赖弗国家儿童健康和人类发展研究所 (NICHD) 的 107 名 GDM 病例受试者和 214 名对照受试者在妊娠 10-14 周和 15-26 周 (GW) 时采集的血液样本测量了 GA 浓度。 ）胎儿生长研究。我们进行了广义线性混合效应回归来测试 GDM 病例受试者和对照受试者之间的平均 GA 差异，并进行了条件逻辑回归来评估 GA 浓度与 GDM 风险之间的前瞻性关联。结果 在 15-26 GW 时，GDM 病例受试者的平均 GA 低于对照受试者（平均 11.90% [95% CI 6.42-32.76] vs. 12.46% [8.45-38.35]，调整后差异 P 值 = 0.004）。一致的是，GA 浓度较高的女性往往具有较低的 GDM 风险，尽管这种关联在统计学上并不显着。结论 这项研究表明，后来患 GDM 的女性在妊娠中期的 GA 浓度可能较低。需要进一步研究来确定其机制。