<br>受聚偏二氟乙烯结构启发的可生物降解铁电分子塑料晶体HOCH2(CF2)7CH2OH,Advanced Materials

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受聚偏二氟乙烯结构启发的可生物降解铁电分子塑料晶体HOCH2(CF2)7CH2OH
Advanced Materials ( IF 27.4 ) Pub Date : 2024-07-06 , DOI: 10.1002/adma.202405981
Yong Ai ₁ , Zhu-Xiao Gu ₂ , Peng Wang _{2,

3} , Yuan-Yuan Tang ₁ , Xiao-Gang Chen ₁ , Hui-Peng Lv ₁ , Peng-Fei Li ₁ , Qing Jiang ₂ , Ren-Gen Xiong ₁ , Jun-Jie Zhang ₄ , Han-Yue Zhang ₃

Affiliation

铁电材料传统上由无机陶瓷和聚合物组成，通常用于医疗植入设备。然而，它们的不可降解性质通常需要进行二次手术才能去除。相比之下，铁电分子晶体具有易于溶液加工、重量轻和生物相容性好的优点，是瞬时（短期）植入设备的有希望的候选者。尽管有这些好处，但由于缺乏有效的设计策略，所发现的可生物降解铁电材料仍然有限。受聚偏二氟乙烯 (PVDF) 极性结构的启发，铁电分子晶体 1H,1H,9H,9H-全氟-1,9-壬二醇 (PFND) 在339 K，被发现。这种转变是通过定向 PFND 分子之间的 O−H···O 相互作用形成的二维氢键网络促进的，这对于铁电性能的表现至关重要。从这个意义上说，通过将-CF ₂ - 基团的数量从PVDF中的约5 000个减少到PFND中的7个，证明这种铁电化合物仅需要简单的溶液处理，同时保持优异的生物安全性、生物相容性和生物可降解性。这项工作阐明了新型可生物降解铁电分子晶体的开发之路，为生物医学应用提供了有前景的途径。

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Biodegradable Ferroelectric Molecular Plastic Crystal HOCH2(CF2)7CH2OH Structurally Inspired by Polyvinylidene Fluoride

Ferroelectric materials, traditionally comprising inorganic ceramics and polymers, are commonly used in medical implantable devices. However, their nondegradable nature often necessitates secondary surgeries for removal. In contrast, ferroelectric molecular crystals have the advantages of easy solution processing, lightweight, and good biocompatibility, which are promising candidates for transient (short-term) implantable devices. Despite these benefits, the discovered biodegradable ferroelectric materials remain limited due to the absence of efficient design strategies. Here, inspired by the polar structure of polyvinylidene fluoride (PVDF), a ferroelectric molecular crystal 1H,1H,9H,9H-perfluoro-1,9-nonanediol (PFND), which undergoes a cubic-to-monoclinic ferroelectric plastic phase transition at 339 K, is discovered. This transition is facilitated by a 2D hydrogen bond network formed through O−H···O interactions among the oriented PFND molecules, which is crucial for the manifestation of ferroelectric properties. In this sense, by reducing the number of −CF₂− groups from ≈5 000 in PVDF to seven in PFND, it is demonstrated that this ferroelectric compound only needs simple solution processing while maintaining excellent biosafety, biocompatibility, and biodegradability. This work illuminates the path toward the development of new biodegradable ferroelectric molecular crystals, offering promising avenues for biomedical applications.

更新日期：2024-07-06

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