With devastating health and socioeconomic impact worldwide, much work is left to understand the Coronavirus Disease 2019 (COVID-19), with emphasis in the severely affected elderly population. Here, we present a proteomics study of lung tissue obtained from aged vs. young rhesus macaques (Macaca mulatta) and olive baboons (Papio Anubis) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Using age as a variable, we identified common proteomic profiles in the lungs of aged infected non-human primates (NHPs), including key regulators of immune function, as well as cell and tissue remodeling, and discuss the potential clinical relevance of such parameters. Further, we identified key differences in proteomic profiles between both NHP species, and compared those to what is known about SARS-CoV-2 in humans. Finally, we explored the translatability of these animal models in the context of aging and the human presentation of the COVID-19.

由于 2019 年冠状病毒病 (COVID-19) 对全球健康和社会经济造成了毁灭性的影响，因此仍有大量工作要做，尤其是受影响严重的老年人口。在此，我们对感染严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的老年恒河猴 ( Macaca mulatta ) 和橄榄狒狒 ( Papio Anubis ) 的肺组织进行了蛋白质组学研究。使用年龄作为变量，我们确定了老年感染的非人灵长类动物 (NHP) 肺部的常见蛋白质组谱，包括免疫功能以及细胞和组织重塑的关键调节因子，并讨论了这些参数的潜在临床相关性。此外，我们还确定了两个 NHP 物种之间蛋白质组谱的关键差异，并将其与已知的人类 SARS-CoV-2 进行比较。最后，我们探讨了这些动物模型在衰老和人类呈现 COVID-19 的背景下的可转化性。