Endocrine disruptors (EDs) pose significant risks to human and environmental health, with potential implications for neurotoxicity. This study investigates the synergistic neurotoxic effects of perfluorooctane sulfonate (PFOS) and glyphosate (GLY), two ubiquitous EDs, using SHSY5Y neuronal and C6 astrocytic cell lines. While individual exposures to PFOS and glyphosate at non-toxic concentrations did not induce significant changes, their combination resulted in a marked increase in oxidative stress and neuroinflammatory responses. Specifically, the co-exposure led to elevated levels of interleukin-6, tumor necrosis factor alpha, and interferon gamma, along with reduced interleukin-10 expression, indicative of heightened neuroinflammatory processes. These findings underscore the importance of considering the synergistic interactions of EDs in assessing neurotoxic risks and highlight the urgent need for further research to mitigate the adverse effects of these compounds on neurological health.

中文翻译：

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中枢神经系统的环境内分泌干扰物风险：全氟辛烷磺酸和草甘膦的神经毒性作用


内分泌干​​扰物 (ED) 对人类和环境健康构成重大风险，并具有潜在的神经毒性影响。本研究使用 SHSY5Y 神经元和 C6 星形胶质细胞系研究全氟辛烷磺酸 (PFOS) 和草甘膦 (GLY) 这两种普遍存在的 ED 的协同神经毒性作用。虽然单独接触无毒浓度的全氟辛烷磺酸和草甘膦不会引起显着变化，但它们的组合会导致氧化应激和神经炎症反应显着增加。具体来说，共同暴露导致白细胞介素 6、肿瘤坏死因子 α 和干扰素 γ 水平升高，同时白细胞介素 10 表达减少，表明神经炎症过程加剧。这些发现强调了在评估神经毒性风险时考虑 ED 协同相互作用的重要性，并强调迫切需要进一步研究以减轻这些化合物对神经健康的不利影响。