Approximately 20–30 % of epilepsy patients exhibit negative findings on routine magnetic resonance imaging, and this condition is known as nonlesional epilepsy. Absence epilepsy (AE) is a prevalent form of nonlesional epilepsy. This study aimed to investigate the clinical diagnostic utility of regional homogeneity (ReHo) assessed through the support vector machine (SVM) approach for identifying AE. This research involved 102 healthy individuals and 93 AE patients. Resting-state functional magnetic resonance imaging was employed for data acquisition in all participants. ReHo analysis, coupled with SVM methodology, was utilized for data processing. Compared to healthy control individuals, AE patients demonstrated significantly elevated ReHo values in the bilateral putamen, accompanied by decreased ReHo in the bilateral thalamus. SVM was used to differentiate patients with AE from healthy control individuals based on rs-fMRI data. A composite assessment of altered ReHo in the left putamen and left thalamus yielded the highest accuracy at 81.64 %, with a sensitivity of 95.41 % and a specificity of 69.23 %. According to the results, altered ReHo values in the bilateral putamen and thalamus could serve as neuroimaging markers for AE, offering objective guidance for its diagnosis.

中文翻译：

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基于 rs-fMRI 的成人失神癫痫神经影像标记


大约 20-30% 的癫痫患者在常规磁共振成像中表现出阴性结果，这种情况被称为非病变性癫痫。失神癫痫（AE）是非病变性癫痫的一种常见形式。本研究旨在探讨通过支持向量机 (SVM) 方法评估的区域同质性 (ReHo) 的临床诊断效用，以识别 AE。这项研究涉及 102 名健康个体和 93 名 AE 患者。所有参与者均采用静息态功能磁共振成像进行数据采集。 ReHo 分析结合 SVM 方法用于数据处理。与健康对照个体相比，AE 患者双侧壳核 ReHo 值显着升高，同时双侧丘脑 ReHo 值降低。 SVM 用于根据 rs-fMRI 数据区分 AE 患者与健康对照个体。对左壳核和左丘脑 ReHo 改变的综合评估准确度最高，为 81.64%，敏感性为 95.41%，特异性为 69.23%。结果表明，双侧壳核和丘脑ReHo值的改变可以作为AE的神经影像标志物，为其诊断提供客观指导。