B cell malignancies, comprising over 80 heterogeneous blood cancers, pose significant prognostic challenges due to intricate oncogenic signaling. Emerging evidence emphasizes the pivotal role of disrupted lipid metabolism in the development of these malignancies. Variations in lipid species, such as phospholipids, cholesterol, sphingolipids, and fatty acids, are widespread across B cell malignancies, contributing to uncontrolled cell proliferation and survival.

中文翻译：

---

利用改变的脂质代谢来治疗 B 细胞恶性肿瘤


B 细胞恶性肿瘤包括 80 多种异质性血癌，由于复杂的致癌信号传导，对预后提出了重大挑战。新的证据强调脂质代谢紊乱在这些恶性肿瘤的发展中发挥着关键作用。磷脂、胆固醇、鞘脂和脂肪酸等脂质种类的变化在 B 细胞恶性肿瘤中广泛存在，导致细胞增殖和存活失控。