Thermosensitive hydrogels have gained increasing attention due to their diverse applications in drug delivery and as wearable sensors. However, their practical utility is hampered by their inherent weak mechanical properties. To overcome this limitation, a tough thermosensitive hydrogel was developed by incorporating non-aggregated spherulite nanoparticles into the system. The hydrogel of poly (N-isopropylacrylamide) (PNIPAM) and calcium hydroxide nano-spherulites (CNS) exhibits a broad temperature response from 0 to 100 °C and good thermosensitivity after ten cycles in swelling experiments. The exceptional mechanical properties with a maximum tensile strength of 82.05 kPa, an elongation at break of about 3200 %, which returns to 88 % of its original size after a compressive load of 16.17 MPa, and an adhesion strength to latex of 32.45 kPa. In addition, each gram of PNIPAM/CNS hydrogel can hold 18.488 mg of AMX, which shows its potential application in many fields such as drug delivery, skin healing, bionics, etc.

中文翻译：

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由微小纳米颗粒交联合成的坚韧、粘合和热敏 PNIPAM/CNS 水凝胶


热敏水凝胶由于其在药物输送和可穿戴传感器方面的多种应用而受到越来越多的关注。然而，它们的实际用途因其固有的弱机械性能而受到阻碍。为了克服这一限制，通过将非聚集球晶纳米颗粒纳入系统中，开发了一种坚韧的热敏水凝胶。聚（N-异丙基丙烯酰胺）（PNIPAM）和氢氧化钙纳米球晶（CNS）的水凝胶在0至100°C的范围内表现出广泛的温度响应，并且在溶胀实验中经过十个循环后表现出良好的热敏性。优异的机械性能，最大拉伸强度为 82.05 kPa，断裂伸长率约为 3200%，在 16.17 MPa 的压缩载荷后恢复到原始尺寸的 88%，对乳胶的粘合强度为 32.45 kPa。此外，每克PNIPAM/CNS水凝胶可容纳18.488毫克AMX，这显示了其在药物输送、皮肤愈合、仿生学等许多领域的潜在应用。