INTRODUCTIONDementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle for BRAin health (LIBRA) index, was reduced by the AgeWell.de intervention.METHODSSecondary analyses of the AgeWell trial, testing a multicomponent intervention (including optimization of nutrition, medication, and physical, social, and cognitive activity) in older adults with increased dementia risk. We analyzed data from n = 461 participants with complete information on risk/protective factors comprised by LIBRA at the 24‐month follow‐up. Intervention effects on LIBRA and LIBRA components were assessed using generalized linear models.RESULTSThe intervention reduced LIBRA scores, indicating decreased dementia risk at follow‐up (b = –0.63, 95% confidence interval [CI]: –1.14, –0.12). Intervention effects were particularly due to improvements in diet (odds ratio [OR]: 1.60, 95% CI: 1.16, 2.22) and hypertension (OR: 1.61, 95% CI: 1.19, 2.18).DISCUSSIONThe AgeWell.de intervention reduced dementia risk. However, several risk factors did not improve, possibly requiring more intensive interventions.Highlights The AgeWell.de intervention reduced dementia risk according to LIfestyle for BRAin health (LIBRA) scores. Beneficial effects on LIBRA are mainly due to changes in diet and blood pressure. A pragmatic lifestyle intervention is apt to reduce dementia risk in an at‐risk population.

中文翻译：

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针对认知能力下降的多领域干预对痴呆症风险状况的影响——AgeWell.de 试验的结果


简介 痴呆症风险评分构成了针对认知功能的生活方式干预措施的有希望的替代结果。我们调查了 AgeWell.de 干预措施是否降低了使用大脑健康生活方式 (LIBRA) 指数评估的痴呆风险。方法对 AgeWell 试验进行二次分析，测试多成分干预措施（包括优化营养、药物治疗以及身体、社交）和认知活动）患有痴呆症风险增加的老年人。我们分析了 461 名参与者的数据，并在 24 个月的随访中提供了 LIBRA 所包含的风险/保护因素的完整信息。使用广义线性模型评估对 LIBRA 和 LIBRA 组成部分的干预效果。结果干预降低了 LIBRA 评分，表明随访时痴呆风险降低（b = –0.63，95% 置信区间 [CI]：–1.14，–0.12）。干预效果主要归功于饮食的改善（比值比 [OR]：1.60，95% CI：1.16，2.22）和高血压（OR：1.61，95% CI：1.19，2.18）。讨论 AgeWell.de 干预降低了痴呆风险。然而，一些危险因素并没有改善，可能需要更深入的干预措施。根据大脑健康生活方式 (LIBRA) 评分，AgeWell.de 干预措施降低了痴呆风险。对LIBRA的有益影响主要来自饮食和血压的变化。务实的生活方式干预有助于降低高危人群患痴呆症的风险。