Unabsorbed Fecal Fat Content Correlates with a Reduction of Immunoglobulin a Coating of Gut Bacteria in High-Lard Diet-Fed Mice,Molecular Nutrition & Food Research

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Unabsorbed Fecal Fat Content Correlates with a Reduction of Immunoglobulin a Coating of Gut Bacteria in High-Lard Diet-Fed Mice
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-07-04 , DOI: 10.1002/mnfr.202400078
Emiko Katsumata ₁ , Takeshi Tsuruta ₁ , Kei Sonoyama ₂ , Takashi Yoshida ₃ , Mio Sasaki ₃ , Mao Teraoka ₁ , Tianyang Wang ₁ , Naoki Nishino ₁

Affiliation

Immunoglobulin A (IgA) selectively coats gut bacteria and contributes to regulatory functions in gastrointestinal inflammation and glucose metabolism. Excess intake of lard leads to decrease in the IgA coating of gut bacteria, although the underlying mechanisms remain unknown. This study validates how unabsorbed fat derived from a high-lard diet in the gut affects the IgA coating of bacteria, as assessed in mouse models using three types of dietary fat (lard, medium-, and long-chain triglycerides [MLCTs], and medium-chain triglycerides [MCTs]) exhibiting different digestibilities.

中文翻译：

未吸收的粪便脂肪含量与高猪油饮食喂养小鼠肠道细菌免疫球蛋白的减少相关

免疫球蛋白 A (IgA) 选择性地覆盖肠道细菌，有助于胃肠道炎症和葡萄糖代谢的调节功能。过量摄入猪油会导致肠道细菌 IgA 涂层减少，但其潜在机制仍不清楚。这项研究验证了肠道中高猪油饮食中未吸收的脂肪如何影响细菌的 IgA 涂层，在使用三种膳食脂肪（猪油、中链和长链甘油三酯 [MLCT] 和猪油）的小鼠模型中进行了评估。中链甘油三酯 [MCT]）表现出不同的消化率。

更新日期：2024-07-04

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