Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

中文翻译：

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定义髓源性抑制细胞


髓源性抑制细胞 （MDSC） 是具有强大免疫抑制活性的中性粒细胞和单核细胞谱系细胞。对小鼠和人类的大量研究已经确定了 MDSC 在抑制抗肿瘤反应和确定癌症免疫疗法疗效方面的重要作用。然而，关于它们的身份、个体发育和功能仍然存在很多争议，必须解决这些问题才能发挥其治疗潜力。在这个观点中，Nature Reviews Immunology 邀请了该领域的八位专家分享他们对 MDSC 研究中的关键问题和挑战的看法。在这个观点中，Nature Reviews Immunology 邀请了该领域的八位专家分享他们对 MDSC 研究中的关键问题和挑战的看法。