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Effect of depression and the antidepressant fluoxetine on osseointegration—A pre‐clinical in vivo experimental study
Clinical Oral Implants Research ( IF 4.8 ) Pub Date : 2024-07-04 , DOI: 10.1111/clr.14323 Yundeng Xiaowen 1 , Jingxuan Zhu 2 , Mingming Gong 2 , Ge Meng 2 , Renran Tan 2 , Yanbing Zhang 2 , Zhiyu Chen 1
Clinical Oral Implants Research ( IF 4.8 ) Pub Date : 2024-07-04 , DOI: 10.1111/clr.14323 Yundeng Xiaowen 1 , Jingxuan Zhu 2 , Mingming Gong 2 , Ge Meng 2 , Renran Tan 2 , Yanbing Zhang 2 , Zhiyu Chen 1
Affiliation
ObjectiveThe aim of this study was to explore the effect of depression and selective serotonin reuptake inhibitors on implant osseointegration and bone healing.MethodsForty‐eight 6‐ to 8‐week‐old SPF Sprague–Dawley male rats were randomly divided into four groups: the Control group, the Fluoxetine group, the Depression group and the De&Flu group. The rats in the Depression group and the De&Flu group were subjected to a depression modelling process, and the rats in the Control group and the Fluoxetine group were raised normally. Then, a titanium implant was placed in the right tibia of each rat. In the Fluoxetine group and De&Flu group, fluoxetine was injected subcutaneously daily, while subcutaneously injecting physiological saline in the Control group and Depression group. Collecting serum from the rats used for ELISA. The surgical area was cut for microcomputed tomography and histology observation.ResultsAfter 12 weeks, bone mineral density was lower in the De&Flu group than in the Control group, Depression group and Fluoxetine group. Bone mineral density was also lower in the Depression group and the Fluoxetine group than in the Control group. The percentage of bone–implant contact (BIC%) in De&Flu rats was lower than in the Control, Depression and Fluoxetine groups. The BIC% in the Depression group and the Fluoxetine group was lower than in the Control group.ConclusionsDepression and fluoxetine negatively affect bone density and implant osseointegration independently, and this damaging effect is exacerbated when both factors are present. The mechanism may be related to the dysregulation of the hypothalamic–pituitary–adrenal axis and inflammation in the body.
中文翻译:
抑郁症和抗抑郁药氟西汀对骨结合的影响——临床前体内实验研究
目的探讨抑郁症和选择性 5-羟色胺再摄取抑制剂对种植体骨整合和骨愈合的影响。方法将 48 只 6 至 8 周龄 SPF Sprague-Dawley 雄性大鼠随机分为 4 组:对照组、氟西汀组、抑郁组和流感&流感组。抑郁组和 De&Flu 组大鼠进行抑郁建模过程,对照组和氟西汀组大鼠饲养正常。然后,将钛植入物放置在每只大鼠的右胫骨中。氟西汀组和 De&Flu 组每日皮下注射氟西汀,对照组和抑郁组皮下注射生理盐水。从大鼠收集血清用于 ELISA。切开手术区域进行显微计算机断层扫描和组织学观察。结果12 周后,De&Flu 组骨密度低于对照组、抑郁组和氟西汀组。抑郁组和氟西汀组的骨密度也低于对照组。De&Flu 大鼠骨-植入物接触 (BIC%) 的百分比低于对照组、抑郁组和氟西汀组。抑郁组和氟西汀组的 BIC% 低于对照组。结论抑郁症和氟西汀独立对骨密度和种植体骨结合产生负面影响,当这两个因素同时存在时,这种破坏性影响会加剧。该机制可能与下丘脑-垂体-肾上腺轴的失调和体内炎症有关。
更新日期:2024-07-04
中文翻译:
抑郁症和抗抑郁药氟西汀对骨结合的影响——临床前体内实验研究
目的探讨抑郁症和选择性 5-羟色胺再摄取抑制剂对种植体骨整合和骨愈合的影响。方法将 48 只 6 至 8 周龄 SPF Sprague-Dawley 雄性大鼠随机分为 4 组:对照组、氟西汀组、抑郁组和流感&流感组。抑郁组和 De&Flu 组大鼠进行抑郁建模过程,对照组和氟西汀组大鼠饲养正常。然后,将钛植入物放置在每只大鼠的右胫骨中。氟西汀组和 De&Flu 组每日皮下注射氟西汀,对照组和抑郁组皮下注射生理盐水。从大鼠收集血清用于 ELISA。切开手术区域进行显微计算机断层扫描和组织学观察。结果12 周后,De&Flu 组骨密度低于对照组、抑郁组和氟西汀组。抑郁组和氟西汀组的骨密度也低于对照组。De&Flu 大鼠骨-植入物接触 (BIC%) 的百分比低于对照组、抑郁组和氟西汀组。抑郁组和氟西汀组的 BIC% 低于对照组。结论抑郁症和氟西汀独立对骨密度和种植体骨结合产生负面影响,当这两个因素同时存在时,这种破坏性影响会加剧。该机制可能与下丘脑-垂体-肾上腺轴的失调和体内炎症有关。