Although, during the past decades, substantial advances emerged in identifying major local and systemic factors contributing to initiation and progression of osteoarthritis (OA), some neuroendocrine mechanisms are still not understood or even neglected when thinking about novel therapeutic options. One of which is the sympathetic nervous system that exhibits various OA-promoting effects in different tissues of the joint. Interestingly, the β2-adrenoceptor (AR) mediates the majority of these effects as demonstrated by several in vitro, in vivo as well as in clinical studies. This review article does not only summarize studies of the past two decades demonstrating that the β2-AR plays an OA-promoting role in different tissues of the joint but also aims to encourage the reader to think about next-level research to discover novel and innovative preventive and/or therapeutic strategies targeting the β2-AR in OA.

中文翻译：

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β2-肾上腺素受体对抗骨关节炎——是时候重新思考预防和治疗了


尽管在过去几十年中，在确定导致骨关节炎（OA）发生和进展的主要局部和全身因素方面取得了重大进展，但在考虑新的治疗方案时，一些神经内分泌机制仍然不被理解，甚至被忽视。其中之一是交感神经系统，它在关节的不同组织中表现出各种促进骨关节炎的作用。有趣的是，多项体外、体内以及临床研究表明，β2-肾上腺素受体 (AR) 介导了大部分效应。这篇综述文章不仅总结了过去二十年的研究，证明 β2-AR 在关节的不同组织中发挥着促进 OA 的作用，而且旨在鼓励读者思考下一阶段的研究，以发现新颖和创新的方法针对 OA 中 β2-AR 的预防和/或治疗策略。