Synovitis is a widely accepted sign of osteoarthritis (OA), characterised by tissue hyperplasia, where increased infiltration of immune cells and proliferation of resident fibroblasts adopt a pro-inflammatory phenotype, and increased the production of pro-inflammatory mediators that are capable of sensitising and activating sensory nociceptors, which innervate the joint tissues. As such, it is important to understand the cellular composition of synovium and their involvement in pain sensitisation to better inform the development of effective analgesics.

中文翻译：

---

免疫调节和成纤维细胞动力学驱动炎性滑膜内伤害性关节痛：揭示骨关节炎治疗进展的机制


滑膜炎是骨关节炎 （OA） 的一个广泛接受的体征，其特征是组织增生，其中免疫细胞浸润的增加和驻留成纤维细胞的增殖采用促炎表型，并增加促炎介质的产生，这些介质能够敏感和激活支配关节组织的感觉伤害感受器。因此，了解滑膜的细胞组成及其在疼痛致敏中的参与非常重要，以更好地为有效镇痛药的开发提供信息。