Mammalian somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) via the forced expression of Yamanaka reprogramming factors. However, only a limited population of the cells that pass through a particular pathway can metamorphose into iPSCs, while the others do not. This study aimed to clarify the pathways that chondrocytes follow during the reprogramming process.

中文翻译：

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追踪人类软骨细胞分化途径的逆遗传学


哺乳动物体细胞可以通过强制表达 Yamanaka 重编程因子重编程为诱导多能干细胞 （iPSC）。然而，只有少数通过特定途径的细胞群可以转变为 iPSC，而其他细胞则不会。本研究旨在阐明软骨细胞在重编程过程中遵循的途径。