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Self-Assembly of Multimolecular Components for Engineering Enzyme-Mimetic Materials
Accounts of Materials Research ( IF 14.0 ) Pub Date : 2024-07-04 , DOI: 10.1021/accountsmr.4c00143 Shichao Xu 1 , Yuanxi Liu 1 , Baoli Zhang 1 , Shan Li 1 , Xiangyu Ye 2 , Zhen-Gang Wang 1
Accounts of Materials Research ( IF 14.0 ) Pub Date : 2024-07-04 , DOI: 10.1021/accountsmr.4c00143 Shichao Xu 1 , Yuanxi Liu 1 , Baoli Zhang 1 , Shan Li 1 , Xiangyu Ye 2 , Zhen-Gang Wang 1
Affiliation
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Natural enzymes, with their intricate three-dimensional structures, facilitate a wide array of biochemical reactions with exceptional precision and speed. The catalytic capabilities of enzymes arise from the distinctive structures of their active sites, where functional groups collaborate or aid cofactors (organic or ionic) in binding substrates with specificity and catalyzing transformations. Inspired by the structure–function relationship of enzymes, supramolecular self-assembly, a bottom-up approach in nanofabrication, has been employed to create enzyme-mimetic catalysts. However, accurately replicating enzymatic active sites poses a formidable challenge, primarily because of the intricacies in mimicking the complexity of natural protein folding.
中文翻译：
工程模拟酶材料多分子组分的自组装
天然酶具有复杂的三维结构，能够以卓越的精度和速度促进各种生化反应。酶的催化能力源于其活性位点的独特结构，其中官能团协同或辅助辅因子（有机或离子）特异性结合底物并催化转化。受酶结构与功能关系的启发，超分子自组装（一种自下而上的纳米制造方法）已被用来制造酶模拟催化剂。然而，准确复制酶活性位点提出了巨大的挑战，主要是因为模仿天然蛋白质折叠的复杂性非常复杂。
更新日期：2024-07-04
中文翻译：
工程模拟酶材料多分子组分的自组装
天然酶具有复杂的三维结构，能够以卓越的精度和速度促进各种生化反应。酶的催化能力源于其活性位点的独特结构，其中官能团协同或辅助辅因子（有机或离子）特异性结合底物并催化转化。受酶结构与功能关系的启发，超分子自组装（一种自下而上的纳米制造方法）已被用来制造酶模拟催化剂。然而，准确复制酶活性位点提出了巨大的挑战，主要是因为模仿天然蛋白质折叠的复杂性非常复杂。
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