Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases,Alzheimer's & Dementia

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Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-07-04 , DOI: 10.1002/alz.14081
Daniela Andriuta _{1,

2,

3} , Julie Ottoy ₃ , Myuri Ruthirakuhan ₃ , Ginelle Feliciano ₃ , Allison A Dilliott ₄ , Robert A Hegele ₅ , Fuqiang Gao ₃ , Paula M McLaughlin ₆ , Jennifer S Rabin _{3,

7,

8,

9} , Madeline Wood Alexander _{3,

8} , Christopher J M Scott ₃ , Vanessa Yhap ₃ , Courtney Berezuk ₃ , Miracle Ozzoude ₃ , Walter Swardfager ₃ , Julia Zebarth ₃ , M Carmela Tartaglia ₁₀ , Ekaterina Rogaeva ₁₁ , David F Tang-Wai ₁₀ , Leanne Casaubon ₁₀ , Sanjeev Kumar ₁₂ , Dar Dowlatshahi ₁₃ , Jennifer Mandzia ₅ , Demetrios Sahlas ₁₄ , Gustavo Saposnik ₁₅ , Corinne E Fischer _{15,

16} , Michael Borrie ₅ , Ayman Hassan _{14,

17} , Malcolm A Binns _{18,

19} , Morris Freedman ₁₈ , Howard Chertkow _{9,

18} , Elizabeth Finger ₅ , Andrew Frank _{13,

20} , Robert Bartha ₅ , Sean Symons ₂₁ , Henrik Zetterberg _{22,

23,

24} , Richard H Swartz _{3,

9,

25} , Mario Masellis _{3,

9,

25} , Sandra E Black _{3,

9,

25} , Joel Ramirez _{3,

26} ,

Affiliation

Department of Neurology, Amiens University Medical Center, Amiens, France.
Laboratoire de Neurosciences Fonctionnelles et Pathologies (UR UPJV 4559), Jules Verne University of Picardy, Amiens, France.
Dr. Sandra Black Centre for Brain Resilience and Recovery, LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec, Canada.
Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Toronto, Ontario, Canada.
Nova Scotia Health, Halifax, Nova Scotia, Canada.
Harquail Centre for Neuromodulation, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Rehabilitation Sciences Institute, University of Toronto, Toronto, Ontario, Canada.
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
Department of Psychiatry, Adult Neurodevelopment and Geriatric Psychiatry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
University of Ottawa Brain and Mind Research Institute and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Division of Neurology, Department of Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Li Ka Shing Knowledge Institute, and Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Thunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada.
Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
Division of Biostatistics, Dalla Lana School of Public Health, Toronto, Ontario, Canada.
Bruyère Research Institute, Ottawa, Ontario, Canada.
Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, UK Dementia Research Institute at UCL, London, UK.
Department of Medicine, Neurology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Graduate Department of Psychological Clinical Science, University of Toronto Scarborough, Toronto, Ontario, Canada.

We investigated the effect of perivascular spaces (PVS) volume on speeded executive function (sEF), as mediated by white matter hyperintensities (WMH) volume and plasma glial fibrillary acidic protein (GFAP) in neurodegenerative diseases.

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