Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures,Alzheimer's & Dementia

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Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-07-04 , DOI: 10.1002/alz.13757
Hyun Kim _{1,

2} , Seonjoo Lee _{2,

3,

4} , Alina Levine ₄ , Benjamin Huber ₄ , Howard Andrews _{1,

3} , Nancy A Kerner _{1,

2} , Daniel Cohen ₂ , Scott Carlson ₂ , Sophie A Bell ₂ , Andres M Rivera ₅ , Marc L Gordon ₆ , Sabrina Simoes ₅ , Davangere P Devanand _{1,

2,

5} , Adam M Brickman ₅ , Lon S Schneider ₇ , Philip D Harvey ₈ , Terry E Goldberg _{1,

2,

9}

Affiliation

Department of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA.
Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York, New York, USA.
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA.
Division of Mental Health Data Science, New York State Psychiatric Institute, New York, New York, USA.
Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, and Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Departments of Neurology and Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, The Litwin-Zucker Research Center, Feinstein Institutes for Medical Research, Manhasset, New York, USA.
University of Southern California Keck School of Medicine, Los Angeles, California, USA.
University of Miami Miller School of Medicine, Miami VA Medical Center, Miami, Florida, USA.
Department of Anesthesiology, Columbia University Irving Medical Center, New York, New York, USA.

This study derived composite scores for two novel cognitive measures, the No Practice Effect (NPE) battery and the Miami Computerized Functional Skills Assessment and Training system for use in early-stage Alzheimer's disease (AD) clinical trials. Their psychometric properties and associations with AD risk markers were compared to those of well-established measures.

中文翻译：

阿尔茨海默氏病预防试验 (NoMAD) 项目中 AD 谱系认知和功能的新测量方法：心理测量特性、收敛验证以及与既定测量方法的对比

这项研究得出了两种新颖的认知测量的综合分数，即无练习效果（NPE）电池和迈阿密计算机化功能技能评估和培训系统，用于早期阿尔茨海默病（AD）临床试验。他们的心理测量特性以及与 AD 风险标记的关联与成熟的测量方法进行了比较。

更新日期：2024-07-04

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