Lactococcus lactis KF140 Ameliorates Nonalcoholic Fatty Liver Disease Induced by Nε-Carboxymethyl-Lysine and High-Fat Diet,Molecular Nutrition & Food Research

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Lactococcus lactis KF140 Ameliorates Nonalcoholic Fatty Liver Disease Induced by Nε-Carboxymethyl-Lysine and High-Fat Diet
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-07-04 , DOI: 10.1002/mnfr.202400260
Hye-Bin Lee ₁ , Miri Park ₁ , So-Young Lee ₁ , Sang Keun Ha ₁ , Yoonsook Kim ₁ , Kwang-Won Lee ₂ , Ho-Young Park _{1,

3}

Affiliation

Long-term consumption of excessive dietary advanced glycation end-products such as N^ε-carboxymethyl-lysine (CML), which are produced by the Maillard reaction during food thermal processing, leads to nonalcoholic fatty liver disease (NAFLD) along with high fat consumption. The study previously finds that administration of Lactococcus lactis KF140 (LL-KF140) detoxifies CML by decreasing CML absorption both in a rat model and clinical trial.

中文翻译：

乳酸乳球菌 KF140 改善 Nε-羧甲基赖氨酸和高脂饮食引起的非酒精性脂肪肝

长期摄入过多的高级糖基化终产物，如食品热处理过程中美拉德反应产生的Nε-^羧甲基赖氨酸（CML），会导致非酒精性脂肪肝（NAFLD）以及高脂肪摄入。该研究之前发现，在大鼠模型和临床试验中，服用乳酸乳球菌KF140 (LL-KF140) 可通过减少 CML 吸收来解毒 CML。

更新日期：2024-07-04

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