Functional Impact of the FADS1 rs174546 Single Nucleotide Polymorphism on Serum Lipid Levels: Insights from Molecular Mechanisms and Therapeutic Perspectives in Korean Population,Molecular Nutrition & Food Research

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Functional Impact of the FADS1 rs174546 Single Nucleotide Polymorphism on Serum Lipid Levels: Insights from Molecular Mechanisms and Therapeutic Perspectives in Korean Population
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-07-03 , DOI: 10.1002/mnfr.202400201
Kyun-Hee Lee _{1,

2} , Soon-Hee Kim ₁ , Sunmin Park ₃ , Hyun-Jun Jang ₁ , Min Jung Kim ₁ , Hye Jeong Yang ₁ , Haeng Jeon Hur ₁ , Jin Hee Kim ₁ , Myung-Sunny Kim _{1,

2}

Affiliation

Single nucleotide polymorphisms (SNP) in the fatty acid desaturase 1 (FADS1) gene is suggested as risk factor of metabolic diseases in genome-wide association studies (GWAS). This study hypothesized that FADS1_rs174546T associates with serum triglycerides (TG) in Korean Genome and Epidemiology Study (KoGES). In addition, functional study of SNP genotypes in cultured cells is performed.

中文翻译：

FADS1 rs174546 单核苷酸多态性对血清脂质水平的功能影响：韩国人群的分子机制和治疗视角的见解

在全基因组关联研究 (GWAS) 中，脂肪酸去饱和酶 1 ( FADS1 ) 基因中的单核苷酸多态性 (SNP) 被认为是代谢疾病的危险因素。本研究在韩国基因组和流行病学研究 (KoGES) 中假设FADS1 _rs174546T 与血清甘油三酯 (TG) 相关。此外，还对培养细胞中的 SNP 基因型进行了功能研究。

更新日期：2024-07-03

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